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SPRB

Spruce Biosciencesdistress 7/10 · high distress / dilution risk
$43.91-2%today-94% from 52w high
sprucebio.com14 employeesFounded 2014South San Francisco, CABiotechnology
Nephrology 1
Lead: MPS IIIB
Revenue
pre-revenue
Liquidity
$54M
Runway
1.8 yrs
Shares 1y
+389%

Price & events

-48.5% over 6M
$43.54$64.39$85.24Jan 26Apr 26Jul 26649kdilution: 424B5 offering (2026-04-21)dilution: 424B5 offering (2026-04-20)dilution: 424B5 offering (2026-03-09)financing: 8-K material_agreement (2026-04-22)financing: 8-K material_agreement (2026-03-09)catalyst: tralesinidase alfa (2026-06-30) — click to opencatalyst: tralesinidase alfa (2026-03-31) — click to openrating: B. Riley Securities: Buy (2026-07-13)rating: Guggenheim: Buy (2026-06-16)rating: Jones Trading: Buy (2026-06-09)rating: HC Wainwright & Co.: Buy (2026-06-01)rating: Citizens: Market Outperform (2026-05-14)rating: Craig-Hallum: Buy (2026-04-27)rating: Citizens: Market Outperform (2026-03-10)rating: HC Wainwright & Co.: Buy (2026-03-10)
CatalystRating changeDilutionFinancingdashed = today
-1.5%
1D
-0.8%
1W
-15.8%
1M
-18.7%
3M
-46.1%
6M
-93.7%
1Y
-98.5%
2Y
-99.9%
5Y
-100.0%
All

Overview

Market Cap
$120.85M
Enterprise Value
$72.24M
Volume
4.50K
52 Week Range
$7.00 – $698
Total Shares
2.75M
Float Shares
2.65M
Short %
13.19%
% Held by Insiders
3.52%
% Held by Institutions
31.33%
RVOL
0.06x
Beta
3.21

Pipeline stages · 2 programs

Tralesinidase alfa (TA)
Preclin
Ph1
Ph2
Ph3
Filed
PDUFA
Approved
next 2033-08
Tildacerfont
Preclin
Ph1
Ph2
Ph3
Filed
PDUFA
Approved

Pipeline · 2 trials · 1 upcoming

ReadoutPhaseDrugIndicationEnrollStatus
2033-08
Estimated 50%
readout ~2033-10-15
Phase 3Tralesinidase alfa (TA)fast trackrare pediatricorphanMPS IIIBnot yet recruiting
2025-01-31
Phase 2TildacerfontCongenital Adrenal Hyperplasia, 21-OHD67terminated

Catalyst news & presentations · 3

Approved drugs (0)

  • none — clinical-stage

Capital structure — dilution & financing

Shares out: 2,752,278 · 4 offerings/1y · 2 PIPEs
  • 2026-04-228-Kmaterial_agreement
  • 2026-04-21424B5offering
  • 2026-04-20424B5offering
  • 2026-03-098-Kmaterial_agreement
  • 2026-03-09424B5offering
  • 2026-01-088-Kprivate_placement
  • 2025-12-12424B3offering
🔒 Positioning — Pro
Short interest / days-to-cover, insider buys & sells.
Upgrade to Pro
🔒 Top holders — Pro
Institutional ownership + quarter-over-quarter accumulation/trimming.
Upgrade to Pro

Wall St ratings

strong buy · target $151 (+244% upside) · 8 analysts
  • 2026-07-13B. Riley SecuritiesBuy
  • 2026-06-16GuggenheimBuy
  • 2026-06-09Jones TradingBuy
  • 2026-06-01HC Wainwright & Co.Buy
  • 2026-05-14CitizensMarket Outperform
  • 2026-04-27Craig-HallumBuy

Competitors — MPS IIIB

  • none identified

Not financial advice. Data: ClinicalTrials.gov, SEC EDGAR, FINRA, Nasdaq, Yahoo.