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PRME

Prime Medicine, Inc.distress 7/10 · high distress / dilution risk
$3.00-3%today-55% from 52w high
primemedicine.com146 employeesFounded 2019Cambridge, MABiotechnology
Lead: Wilson Disease
Revenue
pre-revenue
Liquidity
$64M
Runway
0.4 yrs
Shares 1y
+34%

Price & events

-35.9% over 6M
$2.70$3.69$4.68Jan 26Apr 26Jul 2611.4Mdilution: EFFECT shelf_effective (2026-03-04)catalyst: PHASE1,PHASE2 Prime Editing for Wilson Disease (2026-06-30) — click to opencatalyst: PHASE1,PHASE2 Prime Editing for AATD (2026-06-30) — click to opencatalyst: AATD program (Prime Editor) (2026-06-30) — click to openrating: HC Wainwright & Co.: Neutral → Buy (2026-06-29)rating: Oppenheimer: Outperform (2026-03-12)
CatalystRating changeDilutionFinancingdashed = today
-3.1%
1D
-7.0%
1W
-7.6%
1M
-22.0%
3M
-32.4%
6M
-35.5%
1Y
-48.3%
2Y
5Y
-80.5%
All

Overview

Market Cap
$540.95M
Volume
304.47K
52 Week Range
$2.70 – $6.67
Total Shares
180.62M
Float Shares
114.96M
Short %
24.61%
% Held by Insiders
23.76%
% Held by Institutions
66.60%
RVOL
0.08x
Beta
2.27

Pipeline stages · 1 programs

PM359
Preclin
Ph1
Ph2
Ph3
Filed
PDUFA
Approved
next 2030-01

Pipeline · 1 trials · 1 upcoming

ReadoutPhaseDrugIndicationEnrollStatus
2030-01
Estimated 50%
readout ~2030-02-15
Phase 1/2PM359Chronic Granulomatous Disease, Granulomatous Disease, Chronicenrolling by invitation

Catalyst news & presentations · 4

Approved drugs (0)

  • none — clinical-stage

Capital structure — dilution & financing

Shares out: 180,617,451 · 2 offerings/1y · 0 PIPEs
  • 2026-03-04EFFECTshelf_effective
  • 2025-11-07S-3ASRshelf_registration
  • 2025-07-318-Kmaterial_agreement
  • 2025-07-31424B5offering
  • 2025-07-30424B5offering
  • 2024-12-20EFFECTshelf_effective
  • 2024-12-13S-3shelf_registration
🔒 Positioning — Pro
Short interest / days-to-cover, insider buys & sells.
Upgrade to Pro
🔒 Top holders — Pro
Institutional ownership + quarter-over-quarter accumulation/trimming.
Upgrade to Pro

Wall St ratings

buy · target $7 (+138% upside) · 10 analysts
  • 2026-06-29HC Wainwright & Co.Neutral → Buy
  • 2026-03-12OppenheimerOutperform
  • 2025-12-23LifeSci CapitalOutperform
  • 2025-11-11CitigroupNeutral
  • 2025-11-10Chardan CapitalBuy
  • 2025-08-12CitigroupNeutral

Competitors — Wilson Disease

  • RAREUltragenyx Pharmaceutical Inc.$2.7B · D4
  • ETONEton Pharmaceuticals, Inc.$1.2B · D0
  • MNPRMonopar Therapeutics$687M · D1

Not financial advice. Data: ClinicalTrials.gov, SEC EDGAR, FINRA, Nasdaq, Yahoo.